英国科学家提供食管腺癌克隆型扩散模型的证据_食管腺癌

英国剑桥大学Rebecca C. Fitzgerald和牛津大学David C. Wedge研究组的研究，在基因组水平发现支持转移性食管腺癌克隆型扩散模型的证据。相关论文在线发表在2020年1月6日的《自然—遗传学》上。

研究人员通过对来自18位患有EAC患者的388个样品全基因组测序和系统发育分析发现，在90％的患者中，来自原位瘤的多个亚克隆从原发部位非常迅速地扩散，并形成了包括淋巴结和远处组织在内的多个转移灶–这种传播方式被称为“克隆型扩散”。研究人员在尸检中发现，从较早的时间点开始，组织和血液样本中就已经存在转移性亚克隆。这些发现丰富了人类对EAC的理解并且对临床评估也具有重要意义。

据悉，食管腺癌（EAC）的低治愈性促使科学家对其转移方式和扩散时机的研究。

附：英文原文

Title: Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma

Author: Ayesha Noorani, Xiaodun Li, Martin Goddard, Jason Crawte, Ludmil B. Alexandrov, Maria Secrier, Matthew D. Eldridge, Lawrence Bower, Jamie Weaver, Pierre Lao-Sirieix, Inigo Martincorena, Irene Debiram-Beecham, Nicola Grehan, Shona MacRae, Shalini Malhotra, Ahmad Miremadi, Tabitha Thomas, Sarah Galbraith, Lorraine Petersen, Stephen D. Preston, David Gilligan, Andrew Hindmarsh, Richard H. Hardwick, Michael R. Stratton, David C. Wedge, Rebecca C. Fitzgerald

Issue&Volume: 2020-01-06

Abstract: The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread. Whole-genome sequencing and phylogenetic analysis of 388 samples across 18 individuals with EAC showed, in 90% of patients, that multiple subclones from the primary tumor spread very rapidly from the primary site to form multiple metastases, including lymph nodes and distant tissues—a mode of dissemination that we term ‘clonal diaspora’. Metastatic subclones at autopsy were present in tissue and blood samples from earlier time points. These findings have implications for our understanding and clinical evaluation of EAC.

DOI: 10.1038/s41588-019-0551-3

Source: https://www.nature.com/articles/s41588-019-0551-3