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专长:消化道肿瘤(肠癌、胃癌、食道癌、胰腺癌、肝癌)的治疗及研究 长期从事肿瘤内科治疗(化学治疗、靶向治疗)的临床工作及抗癌药物研究。特别擅长消化道肿瘤(肠癌、胃癌、食道癌、胰腺癌、肝癌)的治疗及研究。曾在美国德州安德森(M.D.Anderson)癌症中心工作3年,被MDAnderson癌症中心聘为客座副教授。负责执笔及参与撰写中国版《NCCN结肠癌临床指导原则》、《NCCN直肠癌临床指导原则》、《NCCN胃癌临床指导原则》临床共识,负责、参与了多项国际及国内抗肿瘤新药(细胞毒性药物及靶向治疗药物)的临床试验,是多项国际多中心临床研究的学术委员会委员(SteeringCommitteeMember)。承担了国家863、国家自然科学基金等多项科研课题。 在国内外重要期刊共发表文章150余篇,其中作者(或通讯作者)100余篇,有多篇文章发表在国际上重要的学术期刊上,如《JournalofClinicalOncology》、《Hepatology》、《JournalofCellBiology》、《CancerResearch》、《ClinicalCancerResearch》等。 主要发表文章(近5年years): 1.XuRH*(firstauthor),HuangP.AnewroleforPHDinchemotherapy.CancerCell.2012Aug14;22(2):143-4. 2.SatohT,XuRH*(co-firstauthor),ChungHC,SunGP,DoiT,XuJM,TsujiA,OmuroY,LiJ,WangJW,MiwaH,QinSK,ChungIJ,YehKH,FengJF,MukaiyamaA,KobayashiM,OhtsuA,BangYJ.Lapatinibpluspaclitaxelversuspaclitaxelaloneinthesecond-linetreatmentofHER2-amplifiedadvancedgastriccancerinAsianpopulations:TyTAN--arandomized,phaseIIIstudy.JClinOncol.2014Jul1;32(19):2039-49. 3.ChenDL,WangZQ,ZengZL,WuWJ,ZhangDS,LuoHY,WangF,QiuMZ,WangDS,RenC,WangFH,ChiaoLJ,PelicanoH,HuangP,LiYH,XuRH*(Correspondence).IdentificationofmicroRNA-214asanegativeregulatorofcolorectalcancerlivermetastasisbywayofregulationoffibroblastgrowthfactorreceptor1expression.Hepatology.2014Aug;60(2):598-609. 4.ZengZL,LuoHY,YangJ,WuWJ,ChenDL,HuangP,XuRH*(Correspondence).OverexpressionofthecircadianclockgeneBmal1increasessensitivitytooxaliplatinincolorectalcancer.ClinCancerRes.2014Feb15;20(4):1042-52. 5.WangDS,PatelA,ShuklaS,ZhangYK,WangYJ,KathawalaRJ,RobeyRW,ZhangL,YangDH,TaleleTT,BatesSE,AmbudkarSV,XuRH*(Correspondence),ChenZS.IcotinibantagonizesABCG2-mediatedmultidrugresistance,butnotthepemetrexedresistancemediatedbythymidylatesynthaseandABCG2.Oncotarget.2014Jun30;5(12):4529-42. 6.ChenDL,WangDS,WuWJ,ZengZL,LuoHY,QiuMZ,RenC,ZhangDS,WangZQ,WangFH,LiYH,KangTB,XuRH*(Correspondence).OverexpressionofpaxillininducedbymiR-137suppressionpromotestumorprogressionandmetastasisincolorectalcancer.Carcinogenesis.2013Apr;34(4):803-11. 7.QiuMZ,LiQ,WangZQ,LiuTS,LiuQ,WeiXL,JinY,WangDS,RenC,BaiL,ZhangDS,WangFH,LiYH,XuRH*(Correspondence).HER2-positivepatientsreceivingtrastuzumabtreatmenthaveacomparableprognosiswithHER2-negativeadvancedgastriccancerpatients:aprospectivecohortobservation.IntJCancer.2014May15;134(10):2468-77. 8.WangDS,ChenDL,RenC,WangZQ,QiuMZ,LuoHY,ZhangDS,WangFH,LiYH,XuRH*(Correspondence).ABObloodgroup,hepatitisBviralinfectionandriskofpancreaticcancer.IntJCancer.2012Jul15;131(2):461-8. 9.ChenDL,ZengZL,YangJ,RenC,WangDS,WuWJ,XuRH*(Correspondence).L1campromotestumorprogressionandmetastasisandisanindependentunfavorableprognosticfactoringastriccancer. JHematolOncol.2013Jun27;6:43. 10.WuWJ,ZhangY,ZengZL,LiXB,HuKS,LuoHY,YangJ,HuangP,XuRH*(Correspondence).β-phenylethylisothiocyanatereversesplatinumresistancebyaGSH-dependentmechanismincancercellswithepithelial-mesenchymaltransitionphenotype.BiochemPharmacol.2013Feb15;85(4):486-96.
擅长病种
肺癌,周围神经系统肿瘤,恶性肿瘤的综合治疗,多发性骨髓瘤
擅长语言