医疗特长：从事内分泌代谢疾病临床和研究工作三十多年，在糖尿病、甲状腺疾病(甲亢、甲减、甲状腺炎、甲状腺结节)、垂体－肾上腺疾病、继发性高血压、生长发育异常、骨质疏松症等方面积累了丰富的经验。研究方向：糖尿病胰岛B细胞功能及早期保护、糖尿病慢性并发症发病机理及防治。主要教育和工作经历：1984年毕业于中山医科大学，历经硕士、博士研究生培养2002年-2003年在美国UAB大学研修一年社会兼职：广东省糖尿病学会主任委员广东省健康管理学会代谢与内分泌专业委员会主任委员中华医学会糖尿病分会委员、血糖监测学组副组长广东省内分泌学会常委、广东省内分泌医师学会常委J Diabetes Res 客座主编、Diabetes Res ClinPract客座编辑、ClinEndocrino等特约审稿人中华内分泌代谢杂志、中华糖尿病杂志、中华全科医师杂志、中国糖尿病杂志、国际糖尿病等杂志编委广东省干部保健专家组成员、广东省健康教育专家广东省卫生厅重点实验室主任中山一院内分泌国家药理基地负责人、中山一院内分泌专科医师/住院医师培训基地主任论著：Insulin requirement profiles of short-term intensive insulin therapy in patients with newly diagnosed type 2 diabetes and its association with long-term glycemic remission. Diabetes Res ClinPract. 2015 Feb 21.[Epub ahead of print]Daidzein and genistein fail to improve glycemic control and insulin sensitivity in Chinese women with impaired glucose regulation: A double-blind, randomized, placebo-controlled trial. Mol. Nutr. Food Res. 2015, 59, 240–249Transmembrane Protease Serine 4 Promotes Thyroid Cancer Proliferation via CREB Phosphorylation.Thyroid. 2015 Jan;25(1):85-94.The experimental and clinical aspects of Beta cell function and its underlying mechanism.J Diabetes Res. 2014; 2014:659149. Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2. Endocrine. 2015 Mar;48(2):566-74. Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis. J Diabetes Res. 2014;2014:258695. doi: 10.1155/2014/258695. Short-term continuous subcutaneous insulin infusion combined with insulin sensitizers rosiglitazone, metformin, or antioxidant α-lipoic acid in patients with newly diagnosed type 2 diabetes mellitus.Diabetes TechnolTher. 2013 Oct;15(10):859-69Adverse effect of metformin therapy on serum vitamin B12 and folate: Short-term treatment causes disadvantages? MedHypotheses 2013 Aug;81(2):149-51. Down-regulation of miR-218-2 and its host gene SLIT3 cooperate to promote invasion and progression of thyroid cancer.J ClinEndocrinolMetab. 2013 Aug;98(8):E1334-44.Impact of vitamin D on chronic kidney diseases in non-dialysis patients: a meta-analysis of randomized controlled trials. PLoS One. 2013 Apr 23;8(4):e61387. Fasting plasma glucose after intensive insulin therapy predicted long-term glycemic control in newly diagnosed type 2 diabetic patients.Endocr J. 2013 Jun 30;60(6):725-32. Increased1,5-Anhydroglucitol Predicts Glycemic Remission in Patients with NewlyDiagnosed Type 2 Diabetes Treated with Short-Term Intensive Insulin Therapy. Diabetes TechnolTher. 2012 Sep;14(9):756-61.AttitudesToward Diabetes Affect Maintenance of Drug-Free Remission in Patients WithNewly Diagnosed Type 2 Diabetes After Short-Term Continuous SubcutaneousInsulin Infusion Treatment. DiabetesCare. 2012 Mar;35(3):474-81.. Early intensive insulin therapy attenuates the p38 pathway in the renalcortex and indices of nephropathy in diabetic rats. Endocrine J. 2012 Jan 31;59(1):81-90. The Akt/FoxO1/p27 pathway mediates the proliferative action of liraglutidein β cells. Mol Med Report. 2012Jan; 5(1):233-8. SphingosineKinase 1 Is Overexpressed and Promotes Proliferation in Human Thyroid Cancer.MolEndocrinol. 2011, 25(11): 1858–1866Fulminanttype 1 diabetes mellitus with rhabdomyolysis: Have we overlooked the situation?DiabetesRes ClinPract. 2010 Dec90(3):e47-9.Hyperinsulinaemichypoglycaemia associated with a heterozygous missensemutation of R1174W in the insulin receptor (IR) gene. Clin Endocrinol.2009;71:659-65.Effect of intensive insulin therapy on β-cell function and glycaemiccontrol in patients with newly diagnosed type 2 diabetes. Lancet 2008; 371:1753-60.Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function. Diabetes Care 2004, 27: 2597-2602专著：内分泌及风湿病临床诊断与治疗方案 科学技术文献出版社糖尿病病人关心的300个问题 湖北科学技术出版社处方学概论 湖北科学技术出版社其他主要工作成绩（比如获奖情况）：获奖：国家科技进步奖二等奖（2011年、第2完成人）广东省科技进步一等奖（2008年、第2完成人）教育部科技进步一等奖（2007年、第3完成人）

高血脂,甲状腺疾病,甲亢,水电与酸碱平衡